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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD152 (CTLA-4)
- 亚型:
Hamster IgG1
- 形态:
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
- 保存条件:
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
- 克隆性:
Monoclonal Antibody
- 标记物:
BIOT
- 适应物种:
Mouse
- 宿主:
Hamster
- 应用范围:
FC
- 浓度:
Concentration:0.5 mg/ml
- 靶点:
Clone number:UC10-4F10-11
- 抗体英文名:
CD152 (CTLA-4) Antibody-BIOT;流式抗体
- 抗体名:
CD152 (CTLA-4) Antibody-BIOT;流式抗体
- 规格:
50/500 μg
克隆类型 :Hamster Monoclonal Antibody;Clone number:UC10-4F10-11
货 号 :HT1610359
规 格 :50/500 μg ;
亚 型 :
Hamster IgG1
浓 度 :
Concentration:0.5 mg/ml
缓 冲 液 :
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
产品描述 :
CD152, also known as CTLA-4 or Ly-56, is a 33 kD member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
适用物种 :
Mouse
应用范围 :
FC
应用说明 :
The amount of the reagent is suggested to be used ≤ 1.0 µg/10^6 cells in 100 µl
保存条件 :
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
标 记 物 :
BIOT(其他荧光标记请咨询我们)
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文献和实验白细胞分化抗原及其功能 CTLA-4 属CD28家族成员。CTLA-4为细胞毒性T细胞相关分子,又称CDl52,为同源二聚体,胞膜外区也 有1个IgSF的V样区。 与T细胞识别、黏附和活化有关CD分子的结构 CTLA-4分子结构保守,人和小鼠的胞质区完全相同。CTLA-4与CD28分子有31%同源性。静止T细胞不表达CTLA-4,T细胞活化后CTLA-4呈诱导性表达。V样区高度保守的MYPPPY基序
T-Cell Activation Using mAb to CD3
splenic T-cells and human peripheral T cells stimulated via CD3. Critical parameters include cell density, antibody titer and activation kinetics. Materials 1X sterile PBS Anti-mouse CD3e, Clone 145-2C11 (Functional Grade, Cat. No. 16
细胞形成以及浆细胞抗体的产生。 ②PD-1(CD279),与CTLA-4有24%同源性,胞质区有1个ITIM。PD-1在T细胞呈活化后诱导性表达,其配体为B7―H1/PD-L1(CD274)和B7-DC/PD-L2(CD273),P1)-I与相应配体结合后,胞质区ITIM中酪氨酸发生磷酸化,募集SHP-2,从而抑制T细胞的增殖,抑制IL-2、IL-10和IFN-7等细胞因子的产生,并对B细胞的增殖、分化与Ig分泌及Ig类别转换有抑制作用。 ③BTLA、CD272结构上与CTLA-4
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