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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD62L (L-Selectin)
- 亚型:
Rat IgG2a
- 形态:
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
- 保存条件:
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
- 克隆性:
Monoclonal Antibody
- 标记物:
PerCP
- 适应物种:
Mouse
- 宿主:
Rat
- 应用范围:
FC
- 浓度:
Concentration:0.2 mg/ml
- 靶点:
Clone number:MEL-14
- 抗体英文名:
CD62L (L-Selectin) Antibody-PerCP;流式抗体
- 抗体名:
CD62L (L-Selectin) Antibody-PerCP;流式抗体
- 规格:
25/100 μg
克隆类型 :Rat Monoclonal Antibody;Clone number:MEL-14
货 号 :HT1610267
规 格 :25/100 μg ;
亚 型 :
Rat IgG2a
浓 度 :
Concentration:0.2 mg/ml
缓 冲 液 :
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
产品描述 :
CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte "rolling" on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, glyCAM-1, and MAdCAM-1.
适用物种 :
Mouse
应用范围 :
FC
应用说明 :
The amount of the reagent is suggested to be used ≤ 0.25 µg /10^6 cells in 100 µl
保存条件 :
Store at 4°C and protected from prolonged exposure to light. Do not freeze.
标 记 物 :
PerCP(其他荧光标记请咨询我们)
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文献和实验L-selectin(CD62L,LECAM-1) 白细胞 75~80 PNAd LAM Mel14(小鼠) S
L 选择素 (CD62L)L选择素又称白细胞内皮细胞黏附分子别(LECAM-1)、淋巴结归巢受体和MEL-14。L选择素胞膜外区N端有1个C型凝集素样结构域,1个EGF样结构域和2个CCP结构域。CD62L表达于造血细胞某些分化阶段,包括大多数B细胞和未致敏T细胞以及大多数单核细胞、中性粒细胞和嗜酸粒细胞。PMA、细胞因子或趋化剂刺激淋巴细胞和中性粒细胞后,由于蛋白酶的酶解作用使CD62L迅速消失,而使血浆中可有很高水平的可溶型CD62L。CD62L通过N端C型凝集素样结构同与唾液
2-4 selectin分子的结构模式图 表2-3 selectin 家族的组成、分布及其相应配体 selectin家族成员 分布 分子量(kDa) 配体 L-selectin(CD62L,LECAM-1) 白细胞 75~80 PNAd LAM Mel14(小鼠) S-Lewis x P-selectin 血管内皮细胞,血小板 140 S-Lewis x (CD62P,GMP-140,PADGEM) (凝血酶、组胺、白三烯刺激后从α颗粒内与质膜融合而表达
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