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- 2025年12月05日
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- 保存条件：
4°C, sealed storage, away from moisture and light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
7431-77-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥375.0 |
| 规格： | 10 mg | 产品价格： | ￥600.0 |
| 规格： | 25 mg | 产品价格： | ￥1200.0 |
| 规格： | 50 mg | 产品价格： | ￥1700.0 |
| 规格： | 100 mg | 产品价格： | ￥2750.0 |
| 规格： | 200 mg | 产品价格： | ￥4800.0 |
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Sinapine thiocyanate
CAS No. : 7431-77-8
MCE 国际站：Sinapine thiocyanate
产品活性：Sinapine thiocyanate 是一种从十字花科物种的种子中分离出来的生物碱。Sinapine thiocyanate 具有抗炎，抗氧化，抗肿瘤，抗血管生成和放射防护作用。Sinapine thiocyanate 还是一种乙酰胆碱酯酶 (AChE) 抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：P-glycoprotein | Cholinesterase (ChE)
In Vitro: Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes.
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity.
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease.
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.
In Vivo: Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.
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