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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
344897-95-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥495.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥450.0 |
| 规格： | 10 mg | 产品价格： | ￥720.0 |
| 规格： | 50 mg | 产品价格： | ￥2300.0 |
| 规格： | 100 mg | 产品价格： | ￥3780.0 |
| 规格： | 200 mg | 产品价格： | ￥5670.0 |
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Leukadherin-1
CAS No. : 344897-95-6
MCE 国际站：Leukadherin-1
产品活性：Leukadherin-1 是特异性的白细胞表面整合素 CD11b/CD18 的激动剂。Leukadherin-1 可增加 CD11b/CD18 依赖性细胞对血纤蛋白原的粘附，EC50为 4 μM。Leukadherin-1 增强白细胞对配体 (如 ICAM-1) 和血管内皮的粘附，从而减少白细胞跨内皮迁移和流入损伤部位。Leukadherin-1 抑制先天性炎症信号转导。
研究领域：Cytoskeleton | Immunology/Inflammation
作用靶点：Integrin | Complement System
In Vitro: Leukadherin-1 is a specific agonist of the leukocyte surface integrin CD11b/CD18 (αMβ2; CR3; Mac-1). Leukadherin‐1 pretreatment reduces secretion of interferon (IFN)‐γ, tumour necrosis factor (TNF) and macrophage inflammatory protein (MIP)‐1β by monokine‐stimulated NK cells. Leukadherin‐1 pretreatment also reduces secretion of IL‐1β, IL‐6 and TNF by Toll‐like receptor (TLR)‐2 and TLR‐7/8‐stimulated monocytes.
In Vivo: Leukadherin-1 (1 mg/kg; i.p.; twice daily for 14 days) is beneficial in preventing hyperoxia-induced neonatal lung injury, an experimental model of bronchopulmonary dysplasia (BPD).
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