Lp - PLA2 is specific for vascular inflammation and is a circulating measure of the progression of rupture-prone plaque. Following production by inflammatory cells, this enzyme cleaves oxidized phospholipids,generating pro-inflammatory molecules and oxidized fatty acids. Elevated Lp-PLA2 levels can predict the development of coronary artery disease in apparently healthy individuals and the risk of future adverse cardiac and cerebrovascular events. The Lp-PLA2 tests are meaningful for assessing risk of coronary artery disease and stroke.