Isoginkgetin异银杏素,548-19-6

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Isoginkgetin

CAS No. : 548-19-6

MCE 国际站：Isoginkgetin

产品活性：Isoginkgetin 是一种 pre-mRNA splicing 抑制剂。Isoginkgetin 也抑制 Akt、NF-κB 和 MMP-9 的活性。Isoginkgetin 抑制 20S proteasome，诱导细胞凋亡（apoptosis），激活自噬（autophagy）。

研究领域：Metabolic Enzyme/Protease  |  PI3K/Akt/mTOR  |  NF-κB  |  Apoptosis  |  Autophagy

作用靶点：MMP  |  Akt  |  NF-κB  |  Proteasome  |  Apoptosis  |  Autophagy

In Vitro: Isoginkgetin (0-20 μM, 24 h) inhibits cell invasion in a dose-dependent manner.
?Isoginkgetin (10 μM, 0-24 h) induces the accumulation of ubiquitinated protein cargo into perinuclear aggregates, activates autophagy and induces lysosomal swelling, repositioning, and acidification.
?Isoginkgetin (10 μM, 0-6 h) induces ER stress, impairs the unfolded protein response, and results in accumulation of ERAD substrates.
?Isoginkgetin directly inhibits the chymotrypsin-, trypsin-, and caspase-like activities of the 20S proteasome and impairs NF-κB signaling.
?Isoginkgetin (30 μM, 0-24 h) induces apoptosis in MM cell lines.

In Vivo: Isoginkgetin (4 mg/kg; i.p.; daily for 14 days) shows anti-inflammatory effects.

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