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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
5373-11-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1045.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥380.0 |
| 规格： | 5 mg | 产品价格： | ￥950.0 |
| 规格： | 10 mg | 产品价格： | ￥1450.0 |
| 规格： | 25 mg | 产品价格： | ￥2900.0 |
| 规格： | 50 mg | 产品价格： | ￥5000.0 |
| 规格： | 100 mg | 产品价格： | ￥8000.0 |
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Cynaroside
CAS No. : 5373-11-5
MCE 国际站：Cynaroside
产品活性：Cynaroside (Luteolin 7-glucoside) 是一种具有抗氧化能力的黄酮类化合物。Cynaroside 还是一种流感依赖的 RNA 聚合酶 抑制剂，IC50 为 32 nM。Cynaroside 也是一种应对 2O2 诱导的细胞凋亡的抑制剂，对氧化应激诱导的心血管疾病具有细胞保护作用。Cynaroside 还具有抗细菌、真菌和抗癌活性，以及抗氧化和抗炎活性。
研究领域：Anti-infection | Cell Cycle/DNA Damage | Apoptosis
作用靶点：Influenza Virus | DNA/RNA Synthesis | Apoptosis | Parasite | Bacterial | Fungal
In Vitro: Cynaroside promots macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2, and mitigates sepsis-associated liver inflammatory damage.
?Cynaroside reduces binding of PKM2 to hypoxia-inducible factor-1α (HIF-1α) by abolishing translocation of PKM2 to the nucleus and promoting PKM2 tetramer formation, as well as suppressing phosphorylation of PKM2 at Y105 in vivo and in vitro.
?Cynaroside restores pyruvate kinase activity, inhibits glycolysis-related proteins including PFKFB3, HK2 and HIF-1α, and inhibits glycolysisrelated hyperacetylation of HMGB1 in septic liver.
?Cynaroside protects H9c2 cells against H2O2-induced apoptosis by decreasing ROS generation and inhibiting caspase activation in both the mitochondrial and death receptor pathways.
?Cynaroside maintains mitochondrial function by regulating Bcl-2 protein expression, as well as JNK and P53 expression.
In Vivo: Cynaroside (i.p.; 5mg/kg) reduces binding of PKM2 to hypoxia-inducible factor-1α (HIF-1α) by abolishing translocation of PKM2 to the nucleus and promoting PKM2 tetramer formation, as well as suppressing phosphorylation of PKM2 at Y105.
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