Human GITR ELISA kit

名称Human GITR ELISA kit
货号BMS2210
Reactivity

	Human
Analyte Parameters	GITR
Sample Volume	50 µL
Suitable Sample Types	cell culture supernatant, serum, plasma (EDTA, citrate, heparin)
Sensitivity	9.7 pg/mL
Standard Curve Range	62.3-4000 pg/mL
Components	Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human GITR Biotin-Conjugate anti-human GITR monoclonal antibody Streptavidin-HRP Human GITR Standard lyophilized, 8000 pg/mL upon reconstitution Sample Diluent Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA) Wash Buffer Concentrate 20x (PBS with 1% Tween 20) Substrate Solution (tetramethyl-benzidine) Stop Solution (1M Phosphoric acid) Adhesive Films
Reported Applications	ELISA

Description: The human GITR ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human GITR. The human GITR ELISA is for research use only. Not for use in diagnostic procedures.

Glucocorticoid-induced TNFR-related protein (GITR) is a member of the tumor necrosis factor receptor (TNF-R) and is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18).

GITR is receptor for TNFSF18 and seems to interact with activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR plays role in activation of NF-kappa-B via the TRAF2/NIK pathway.
It has been shown that antibodies to GITR promote an anti-tumor response through loss of Treg lineage stability.
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