活性:
Measured by its binding ability in a functional ELISA.Immobilized VEGFR2/R3-Fc at 5 µg/mL (100 µl/well) can bind Human VEGF-B, His Tag (Cat# VE6-H5225 ) .The EC50 is typically 0.01-0.12 µg/mL.
产品背景:
Vascular endothelial growth factor B (VEGFB) is also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
产品描述:
Human VEGF-B, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 20.2 kDa. The predicted N-terminus is Pro 22. The reducing (R) protein migrates as 15-18 kDa and 33-35 kDa in SDS-PAGE.