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文献和实验Genotyping for Cytochrome P450 Polymorphisms
Protocols for the extraction of DNA from human blood and for genotyping for a number of common cytochrome P450 polymorphisms using either polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR-single-strand
Analysis of Cytochrome P450 Polymorphisms
of known polymorphisms in cytochrome P450 genes. Methods for phenotypic detection of polymorphisms in CYP2D6 and CYP2A6 are also described.
This chapter provides a detailed description of methodology used to assess the cytochrome P450 inhibition potential of small molecules using fluorometric substrates in a multiwell plate format. Inhibition of cytochromes P450 can result
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