A synthetic peptide corresponding to a sequence at the N-terminus of human ST13(1-19aa MDPRKVNELRAFVKMCKQD), different from the related rat and mouse sequences by two amino acids.
亚型:
Rabbit IgG
形态:
Liquid
保存条件:
12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
克隆性:
单克隆
适应物种:
human,mouse,rat
抗原来源:
Rabbit
库存:
现货
供应商:
博士德生物
应用范围:
WB
浓度:
500ug/ml
规格:
50ul/100ul/150ul
规格:
50ul
产品价格:
¥860.0
规格:
100ul
产品价格:
¥1520.0
规格:
150ul
产品价格:
¥2280.0
产品概况
货号
BA2857-2
产品名称
ANTI-ST13 Antibody
基因名
ST13
抗体来源
Rabbit
克隆
Polyclonal
抗体亚型
Rabbit IgG
免疫原
A synthetic peptide corresponding to a sequence at the N-terminus of human ST13(1-19aa MDPRKVNELRAFVKMCKQD), different from the related rat and mouse sequences by two amino acids.
内容
500ug/ml antibody with PBS ,0.02% NaN3 , 1mg BSA
纯化方式
Immunogen affinity purified.
浓度
500ug/ml
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料
ST13(Suppression of Tumorigenicity 13), also known as P48 or HIP, is a protein that in humans is encoded by the ST13 gene. ST13 is an abundant, highly conserved protein that binds the major cytosolic chaperones heat-shock protein 70-kD(HSP70) and HSP90 during an intermediate stage of steroid receptor assembly, but is absent from the mature receptor complex. Zhang et al.(1998) mapped the ST13 gene to chromosome 22q13 by fluorescence in situ hybridization. They noted that colorectal, breast, and ovarian carcinomas frequently show loss of heterozygosity at this site. Using a yeast 2-hybrid assay, Hohfeld et al.(1995) showed that rat Hip bound Hsc70(HSPA8). One Hip oligomer bound the ATPase domains of at least 2 Hsc70 molecules, and binding was dependent on activation of the Hsc70 ATPase by Hsp40(DNAJB1). Hip stabilized the ADP-bound form of Hsc70, which had a high affinity for a test protein substrate. Hohfeld et al.(1995) concluded that HIP contributes to interactions of HSC70 with target proteins through its own chaperone activity.
研究类别
1. Hohfeld, J., Minami, Y., Hartl, F.-U. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Cell 83: 589-598, 1995.2. Prapapanich, V., Chen, S., Nair, S. C., Rimerman, R. A., Smith, D. F. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. Molec. Endocr. 10: 420-431, 1996.3. Zhang, Y., Cai, X., Schlegelberger, B., Zheng, S. Assignment of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-q25 by in situ hybridization. Cytogenet. Cell Genet. 83: 56-57, 1998.
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0001-1) for IHC(P). *Blocking peptide 可以联系我们购买。