Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes. .
Tissue Specificity
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. .
Sequence Similarities
Lipoma-preferred partner;LIM domain-containing preferred translocation partner in lipoma;LPP;
LIM domain containing preferred translocation partner in lipoma. The Zyxin family of proteins contains five members, Ajuba, LIMD1, LPP,TRIP6 and Zyxin. LPP (LIM-containing lipoma-preferred partner), a LIM domain-containing scaffolding protein contains three LIM domains at its carboxyterminus, which are preceded by a proline-rich pre-LIM region containing a number of protein interaction domains. LPP, an 80 kDa protein, localizes to sites of cell adhesion, such as focal adhesions and cell-cell contacts,and shuttles to the nucleus where it has transcriptional activation capacity.The human LPP gene maps to chromosomal location 3q28, and preferentiallytranslocates to the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas.
[list_product_images]LPP(BM1972)(MW:66KD)Hela,NIH3T3,COS7,Caki,MCF-7,HepG2,SMMC细胞裂解,免疫印迹分析。|Immunohistochemical analysis of paraffin-embedded human small intestine using LPP mouse mAb with DAB staining.|Immunohistochemical analysis of paraffin-embedded human vessels tissues using LPP mouse mAb.|Confocal immunofluorescence analysis of COS cells using LPP mouse mAb (green). Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.|Confocal immunofluorescence analysis of Hela cells using LPP mouse mAb (green). Red: Actin filaments have been labeled using DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.[/list_product_images]