Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD5 is required for normal development of the cardiovascular system in vivo; lack of the SMAD5 gene results in apoptosis of cardiac myocytes. 3 Upregulation of SMAD5 has been reported to mediate apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. Tissue specificity: Ubiquitous.
[list_product_images]SMAD5(BM3079)(MW:52KD)PC-12,Jurkat,K562细胞裂解,免疫印迹分析。|Immunohistochemical analysis of paraffin-embedded brain tissues (left) and lung cancer tissues (right) using SMAD5 mouse mAb with DAB staining.|Flow cytometric analysis of Jurkat cells using SMAD5 mouse mAb (green) and negative control (purple).[/list_product_images]