Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.
Sequence Similarities
Protein S100-A10;Calpactin I light chain;Calpactin-1 light chain;Cellular ligand of annexin II;S100 calcium-binding protein A10;p10 protein;p11;S100A10;ANX2LG, CAL1L, CLP11;
S100 calcium binding protein A10 (S100A10/P11), it is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis.