Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung. .
Tissue Specificity
May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. .
Sequence Similarities
BPI fold-containing family B member 1;Long palate, lung and nasal epithelium carcinoma-associated protein 1;Von Ebner minor salivary gland protein;VEMSGP;BPIFB1;C20orf114, LPLUNC1;UNQ706/PRO1357;
Palate, lung, and nasal epithelium clone (Plunc, now renamed Splunc1) is a small secreted protein expressed in the oropharynx and upper airways of humans, mice, rats, and cows. This protein is structurally homologous to known mediators of host defense against gram-negative bacteria.