Highly expressed in early fetal tissues, including those of the central nervous system.
Tissue Specificity
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. .
Sequence Similarities
DNA-binding protein inhibitor ID-2;Class B basic helix-loop-helix protein 26;bHLHb26;Inhibitor of DNA binding 2;Inhibitor of differentiation 2;ID2;BHLHB26;
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3.
[list_product_images]Immunohistochemical analysis of paraffin-embedded breast cancer tissues using ID2 mouse mAb with DAB staining.|Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ID2 mouse mAb with DAB staining.|Flow cytometric analysis of SK-N-SH cells using ID2 mouse mAb (green) and negative control (purple).|Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng);[/list_product_images]