Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades (see LILRA1, MIM 604810). One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor (Borges et al., 1997 [PubMed 9548455]).[supplied by OMIM
Gene Description:
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
Gene Alias:
CD85E,HM31,HM43,ILT6,LIR-4,LIR4,e3
Gene Name:
LILRA3
Storage Instruction:
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
Supplied Product:
Antibody pair set content: 1. Capture antibody: mouse monoclonal anti-LILRA3 (100 ug) 2. Detection antibody: rabbit purified polyclonal anti-LILRA3 (50 ug) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
Quality Control Testing:
Standard curve using LILRA3 293T overexpression lysate (non-denatured) as an analyte. Sandwich ELISA detection sensitivity ranging from approximately 243x to 3x dilution of the LILRA3 293T overexpression lysate (non-denatured).
Reactivity:
Human
Product Description:
This antibody pair set comes with matched antibody pair to detect and quantify protein level of human LILRA3.