Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at 4°C for short term. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In PBS (0.09% sodium azide)
Recommend Usage:
Western Blot (1:1000) The optimal working dilution should be determined by the end user.
Form:
Liquid
Specificity:
Sequence has 85% identity with canine, 82% identity with horse and 80% identity with bovine. This antibody is useful for Western blot, where a band is seen ~38KDa due to glycosylation.
Reactivity:
Human
Host:
Rabbit
Immunogen:
Recombinant protein corresponding to full length human KLK6.
Product Description:
Rabbit polyclonal antibody raised against full length recombinant KLK6.