This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq
omim id:
, ,
Gene Description:
cholinergic receptor, nicotinic, alpha 4
Gene Alias:
BFNC,EBN,EBN1,FLJ95812,NACHR,NACHRA4,NACRA4
Gene Name:
CHRNA4
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Recommend Usage:
ELISA (1:4000) The optimal working dilution should be determined by the end user.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Concentration:
0.5 mg/mL
Purification:
Antigen affinity purification
Form:
Liquid
Theoretical MW (kDa):
70
Host:
Goat
Sequence:
C-RASSHVETRAHAE
Immunogen:
A synthetic peptide corresponding to human CHRNA4.
Product Description:
Goat polyclonal antibody raised against synthetic peptide of CHRNA4.