membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase,protein kinase Myt1
Gene Summary:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Gene Description:
protein kinase, membrane associated tyrosine/threonine 1
Gene Alias:
DKFZp547K1610,FLJ20093,MYT1
Gene Name:
PKMYT1
Storage Instruction:
Store at -20°C. Avoid repeated freezing and thawing.
Storage Buffer:
In PBS, pH 7.4 (without Mg and Ca), (50% glycerol, 0.02% sodium azide)
Recommend Usage:
Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
Purification:
Affinity purification
Form:
Liquid
Specificity:
This antibody detects endogenous levels of PKMYT1 only when phosphorylated at serine 83.
Reactivity:
Human
Theoretical MW (kDa):
54
Host:
Rabbit
Immunogen:
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S83 of human PKMYT1.
Product Description:
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human PKMYT1.