Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
omim id:
,
Gene Description:
matrix metallopeptidase 13 (collagenase 3)
Gene Alias:
CLG3
Gene Name:
MMP13
Storage Instruction:
Store at 4°C. For long term storage store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In TBS, pH 7.2 (BSA, 10% Proclin300)
Recommend Usage:
Western Blot (0.1-1 ug/mL) ELISA (0.01-0.1 ug/mL) Immunoprecipitation (2-5 ug/mL) Immunohistochemistry (1:100) The optimal working dilution should be determined by the end user.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Form:
Liquid
Specificity:
This antibody recognizes ~60 and 48 KDa human MMP13.
Reactivity:
Human, Mouse, Rat
Theoretical MW (kDa):
60, 48
Host:
Rabbit
Immunogen:
A synthetic peptide corresponding to the hinge region of human MMP13.
Product Description:
Rabbit polyclonal antibody raised against synthetic peptide of MMP13.