Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq
omim id:
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Gene Description:
catechol-O-methyltransferase
Gene Alias:
-
Gene Name:
COMT
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at 4°C. For long term storage store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In PBS (0.09% sodium azide)
Recommend Usage:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.5-5 ug/mL) The optimal working dilution should be determined by the end user.
Purification:
Immunoaffinity chromatography
Form:
Liquid
Specificity:
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reactivity:
Human
Host:
Rabbit
Immunogen:
A synthetic peptide corresponding to 19 amino acid at internal region of human COMT.
Product Description:
Rabbit polyclonal antibody raised against synthetic peptide of COMT.