Wingless-type MMTV integration site family, member 1 (oncogene INT1)
Gene Summary:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq
Gene Description:
wingless-type MMTV integration site family, member 1
Gene Alias:
INT1
Gene Name:
WNT1
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at 4°C. For long term storage store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In PBS (0.09% sodium azide)
Recommend Usage:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/ml) The optimal working dilution should be determined by the end user.
Purification:
Immunoaffinity chromatography
Form:
Liquid
Specificity:
BLAST analysis of the peptide immunogen showed no homology with other human proteins.