This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq
Gene Description:
coagulation factor IX
Gene Alias:
FIX,HEMB,MGC129641,MGC129642,PTC
Gene Name:
F9
Regulation Status:
For research use only (RUO)
Detection Method:
Colorimetric
Label:
Biotin-conjugate
Sample Volume:
50 uL
Suitable Sample:
Cell Culture Samples, CSF, Plasma, Serum
Storage Instruction:
Store components of the kit at 4°C or -20°C as described in the protocol.
Reactivity:
Human
Limit of Detection:
0.4 ng/mL
Calibration Range:
1.563 to 100 ng/mL
Product Description:
F9 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human F9.