ubiquitin conjugating enzyme 7 interacting protein 1
Gene Summary:
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq
Gene Description:
ring finger protein 216
Gene Alias:
TRIAD3,U7I1,UBCE7IP1,ZIN
Gene Name:
RNF216
Protein Accession#:
AAO60361;Q9NWF9-3
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In PBS (0.09% sodium azide)
Recommend Usage:
Western Blot (1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
Purification:
Protein G purification
Form:
Liquid
Reactivity:
Human, Mouse
Host:
Rabbit
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human RNF216.
Product Description:
Rabbit polyclonal antibody raised against synthetic peptide of RNF216.