This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq
omim id:
,
Gene Description:
vascular endothelial growth factor A
Gene Alias:
MGC70609,VEGF,VEGF-A,VPF
Gene Name:
VEGFA
Regulation Status:
For research use only (RUO)
Detection Method:
Colorimetric
Label:
Biotin-conjugated
Sample Volume:
100 uL
Suitable Sample:
Body Fluid, Cell Culture Supernatant, Plasma, Serum, Tissue Lysate
Storage Instruction:
Store at 4°C for 4 months, or at -20°C for 8 months.
Quality Control Testing:
Standard Curve The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Reactivity:
Human
Limit of Detection:
1 pg/mL
Calibration Range:
31.2 to 2000 pg/mL (Serum, Plasema, Body Fluid) 15.6 to 1000 pg/mL (Cell Culture Supernate)
Product Description:
VEGFA (Human) ELISA Kit is intended for the quantitative measurement of human VEGFA.