前列腺癌PCR基因芯片 Prostate Cancer PC

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Prostate Cancer PCR Array

前列腺癌PCR基因芯片

Product	Species	Technology	Cat. No.
Prostate Cancer PCR Array	Human	Gene Expression	PAHS-135Z
Prostate Cancer PCR Array	Mouse	Gene Expression	PAMM-135Z
Prostate Cancer PCR Array	Rat	Gene Expression	PARN-135Z

Prostate Cancer RT² Profiler PCR Array profiles the expression of 84 key genes commonly involved in prostate cancer development. One of the top lethal cancers in the United States, prostate cancer is a neoplasm of the male reproductive gland that manifests primarily after the age of fifty. The molecular cause of prostate cancer is still unclear, but is often associated with deregulated androgen signaling and aberrant metabolism of macromolecules such as fatty acids. Indeed, androgen ablation therapy causes regression of primary and metastatic androgen-dependent prostate cancer. Androgen receptor expression seems to promote prostate cancer cell survival, but inhibiting the androgen receptor has, so far, been clinically less effective than predicted. Polyunsaturated fatty acids cause prostate tumor progression and increased mortality, while diets rich in omega-3 fatty acids seem to benefit prostate cancer patients. Research directed at these pathways may yield insights into the molecular mechanisms behind prostate oncogenesis. This array represents genes involved in androgen receptor, PI3 kinase/AKT, and PTEN signaling, as well as the cell cycle and apoptotic pathways. The 84 key genes also include deregulated genes detected routinely in molecular analysis of prostate cancer samples and in high-throughput microarray profiling studies, as well as genes known to have differentially methylated promoters in prostate cancer. Prostate cancers tend to metastasize; therefore, the array includes genes associated with metastatic potential. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in prostate cancer initiation, progression, and metastasis with this array.
前列腺癌PCR基因芯片可以同时检测与前列腺癌的发展相关的84个关键基因的表达。前列腺癌在美国是致命性最高的癌症之一，主要表现为50岁以后的男性生殖腺的肿瘤。前列腺癌的分子病因目前还不清楚，但往往与雄激素信号和异常代谢的大分子物质（如脂肪酸）调节失控有关。事实上，雄激素消融治疗会引起原发性和转移性雄激素非依赖性前列腺癌的复发。截止目前，雄激素受体的表达会促进前列腺癌细胞的生存；而抑制雄激素受体的临床效果远低于预测。多不饱和脂肪酸会加速前列腺肿瘤的进展、增加死亡率，然而饮食中丰富的omega-3脂肪酸则前列腺癌患者有益。关于这些相关途径的研究可能会有助于我们更深入的理解前列腺肿瘤发生的分子机制。该芯片包括雄激素受体，PI3K/AKT和PTEN的信号通路基因，细胞周期和细胞凋亡通路相关的基因，前列腺癌检测的常规基因，以及对前列腺癌样本进行高通量芯片筛选出的一些重要基因。由于前列腺癌往往会有迁移的情况，因此该芯片同样包括肿瘤转移相关的基因。利用实时定量PCR，研究者可以方便并且可信地对前列腺癌症相关基因进行同时检测。
Differentially Methylated Promoters:APC, AR, CAV1, CCNA1, CDH1 (E-cadherin), CDKN2A, DKK3, DLC1, EDNRB, GPX3, GSTP1, MGMT (AGT), MSX1, PDLIM4 (RIL), PTGS2 (COX2), RARB, RASSF1, SFRP1, SLC5A8, TIMP2, TNFRSF10D, ZNF185.
Up-Regulated in Prostate Cancer:ARNTL, CAMSAP1, DDX11, ECT2, ETV1, HAL, IGFBP5, KLK3, MTO1, PDPK1, RBM39, SOCS3, SOX4, SUPT7L.
Down-Regulated in Prostate Cancer:CCND2, CLN3, GCA, IGF1, LGALS4, LOXL1, PPP2R1B, SFRP1, SLC5A8, TFPI2, USP5.
Metastatic Potential:CREB1, KLHL13, MAX, NDRG3, PES1, SEPT7, SCAF11 (SFRS2IP).
Androgen Signaling:AR, CAV1, CCND1, DAXX, EGFR, FOXO1, GNRH1, IGF1, IL6, NFKB1, NRIP1, PTEN, SHBG, TGFB1I1, TIMP2, TIMP3, VEGFA.
PI3K/AKT Signaling:AKT1, AR, BCL2, CCND1, CCND2, CDH1 (E-cadherin), CDKN2A (p16INK4), EGFR, FOXO1, GNRH1, IGF1, IL6, MAPK1 (ERK2), NFKB1, PDPK1, PTEN, TIMP2, TIMP3, TNFRSF10D, TP53, VEGFA.
PTEN Signaling:AKT1, EGFR, GNRH1, IGF1, IL6, MAPK1 (ERK2), PDPK1, PTEN, TIMP2, TIMP3, TP53, VEGFA.
Apoptosis:BCL2, CASP3, CDKN2A (p16INK1), EGFR, ETV1, GNRH1, IGF1, IL6, MAPK1, NFKB1, PTEN, TIMP2, TIMP3, TP53, VEGFA.
Cell Cycle:APC, BCL2, CASP3, CAV2, CCNA1, CCND1, CCND2, CDKN2A (p16INK4), EGFR, IGF1, PPP2R1B, PTEN, PTGS1, PTGS2 (COX2), TP53.
Transcription Factors:AR, ARNTL, CDKN2A (p16INK4), CREB1, DAXX, EGR3, ERG, ETV1, FOXO1, MAX, MSX1, NFKB1, NKX3-1, NRIP1, RARB, RBM39, SOX4, SREBF1, SUPT7L, TP53.
Fatty Acid Metabolism:ACACA, CAMKK1, FASN, HMGCR, IGF1, PRKAB1, SREBF1, STK11 (LKB1).
Others:MKI67, TMPRSS2.