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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
942206-85-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1082.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥333.0 |
| 规格： | 5 mg | 产品价格： | ￥750.0 |
| 规格： | 10 mg | 产品价格： | ￥1234.0 |
| 规格： | 25 mg | 产品价格： | ￥2475.0 |
| 规格： | 50 mg | 产品价格： | ￥3713.0 |
| 规格： | 100 mg | 产品价格： | ￥5569.0 |
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GSK1016790A
CAS No. : 942206-85-1
MCE 国际站：GSK1016790A
产品活性：GSK1016790A 是有效的，选择性瞬时受体电位香草酸 4 (TRPV4) 通道激活剂。GSK1016790A 可以引起 HEK 细胞中 Ca2+ 流入并升高细胞内 Ca2+。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：TRP Channel | Calcium Channel
In Vitro: GSK1016790A (0.1-1000 nM) elicits Ca2+ influx in mouse and human TRPV4-expressing human embryonic kidney (HEK) cells (EC50 values of 18 and 2.1 nM, respectively) and it evokes a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. GSK1016790A (100 nM) treatment elicits a rapid elevation of intracellular Ca2+ in a subset of neurons.
In Vivo: GSK1016790A (0.001-0.1 mg/kg; i.p.) produces a dose-dependent inhibitory effect on whole gut transit time in mice.
GSK1016790A (0.1-1000 nM; pretreatment 10 min) significantly inhibits the electrical field stimulation (EFS)-induced twitch contractions in isolated mouse colon strips in a concentration-dependent manner.
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文献和实验真爱满行囊 我最近在体外细胞做的关于gsk3-beta功能问题，发现药物处理以后，gsk-3-beta的总表达量下调，如果是这样的话 1、我是否能够得出gsk-3-beta的活性下调的结论？ 2、是否还有必要做非活性形式的表达量？我的理解是，基础状态下，gsk-3beta维持的是低活性状态，如果总量都下调了，那应该能够得出活性降低的结论了吧？ 3、另外，在这种情况下我是否有必要去做gsk-3-beta的216位点的活性形式的表达
. The activity of these targets leads to survival, cytoskeletal rearrangement and transformation. GSK3 β lycogen synthase kinase-3; NF-κB, nuclear factor of κB; PDK1/2, 3-phosphoinositide-dependent protein kinase 1/2.
kinase (AMPK) exert opposing effects on mammalian target of rapamycin (mTOR), which is activated by AKT. ERK, extracellular signal regulated kinase; FKHR, forkhead; GDP, guanosine diphosphate; IRS, insulin receptor substrate; GSK3, glycogen synthase
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