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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SCIO-469
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
309913-83-5
- 规格：
10 mM * 1 mL/1 mg/2 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1125.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥550.0 |
| 规格： | 2 mg | 产品价格： | ￥810.0 |
| 规格： | 5 mg | 产品价格： | ￥997.0 |
| 规格： | 10 mg | 产品价格： | ￥1850.0 |
| 规格： | 25 mg | 产品价格： | ￥3885.0 |
| 规格： | 50 mg | 产品价格： | ￥5640.0 |
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Talmapimod
CAS No. : 309913-83-5
MCE 国际站：Talmapimod
产品活性：Talmapimod (SCIO-469) 是 p38α 选择性的，具有口服活性的，ATP 竞争性的抑制剂，IC50 值是 9 nM，约为 p38β 的10倍，在 20 个其他激酶 (包括其他 MAPKs) 上显示出至少 2000 倍的选择性。
研究领域：MAPK/ERK Pathway
作用靶点：p38 MAPK
In Vitro: Talmapimod (SCIO-469) (100-200 nM; 1 hour) inhibits phosphorylation of p38 MAPK in MM cells.
Talmapimod inhibits LPS-induced TNF-a production in human whole blood.
Talmapimod decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells.
In Vivo: Targeting p38α MAPK with Talmapimod (SCIO-469) decreases myeloma burden in addition to preventing the development of myeloma bone disease.
Talmapimod inhibits multiple myeloma growth and prevents bone disease in the 5T2MM and 5T33MM models.
Talmapimod (10-90 mg/kg; p.o.; twice daily orally for 14 days) dose-dependently reduced tumor growth and also dose-dependently reduced weight of the palpable tumors at termination.
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