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- Cell Signaling Technology
- 9807
- USA
- 2025年08月03日
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文献和实验Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate
tissue. Small-molecule peptides as well as monoclonal antibodies have been used as TVs. The synthesis, antigen binding, and cytotoxicity of a covalent conjugate of the anticancer drug paclitaxel (taxol) to the anti-epidermal growth factor receptor (EGFR
Antisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a Model
(paclitaxel; Fig. 1 ), an important antineoplastic agent that is used extensively in treating several types of malignancies including ovarian, breast, and lung, as well as melanomas (2 –5 ).
High-Performance Liquid Chromatographic Analysis of CYP2CSCatalyzed Paclitaxel 6-Hydroxylation
2C8, although studies with lmmunologically purified or cDNA-expressed CYP2C8 have indicated that this P450 catalyzes the metabohsm of retmol(6 ), retinolc acid (6 ), arachldonic acid (7 , 8 ), carbamazepine (9 ) and paclitaxel (10 –12 ). Oxldatlon
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