Evatanepag,223488-57-1

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Evatanepag

CAS No. : 223488-57-1

MCE 国际站：Evatanepag

产品活性：Evatanepag (CP-533536) 是一种非前列腺素的，有效的和选择性的 EP₂ 受体 激动剂。 Evatanepag 可诱导局部骨形成 (in vivo)。Evatanepag 可用于骨折、骨缺损、哮喘的研究。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vitro: Evatanepag (10 nM, 30 min) inhibits hFcεRI-induced mast cells degranulation in a dose-dependent manner.
Evatanepag (0.1 nM-10 μM, 12 min) results in an equivalent increase in intracellular cAMP in HEK-293 cells, with an IC₅₀ of 50 nM.

In Vivo: Evatanepag (0.3-3.0 mg/kg, directly injected into the marrow cavity of the tibia) promotes bone formation in rats.
Evatanepag (0.3, 3.0 mg/kg, intranasal administration, from day1 to day4) reduces HDM aeroallergen-induced increased RL response to methacholine in mice.
Evatanepag (1 mg/kg, intravenous injection) demonstrates high i.v. clearance (Cl: 56 mL/min/kg) and a short half-life (t_1/2: 0.33 h).

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