ALS-8112,1445379-92-9

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ALS-8112

CAS No. : 1445379-92-9

MCE 国际站：ALS-8112

产品活性：ALS-8112是高效，选择性的呼吸道合胞病毒（RSV）聚合酶抑制剂。5'-三磷酸形式的ALS-8112抑制RSV聚合酶，IC₅₀值为0.02 μM。

研究领域：Anti-infection

作用靶点：RSV

In Vitro: The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC₅₀ of 0.020 ± 0.008 μM.

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