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- 2025年12月29日
- rabbit
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rabbit
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文献和实验Transgenic Targeting of a Dominant Negative Corepressor to Liver and Analyses by cDNA Microarray
in the absence of ligand and activate transcription upon ligand binding in positively-regulated target genes (1 –3 ). TRs and RARs mediate basal repression through interactions with corepressors, such as nuclear receptor corepressor (NcoR ) and silencing
Characterization of Nuclear Receptor Ligands by Multiplexed Peptide Interactions
, although described for nuclear receptors, may also be applied to other types of molecular interactions. Keywords: Microsphere; flow cytometry; nuclear receptor; coactivator; corepressor; cofactor; agonist; antagonist; ligand; ligand binding
The yeast two-hybrid system is a powerful tool for the isolation and characterization of nuclear receptor interacting proteins such as coactivator and corepressor proteins. Generally coactivators associate with the nuclear receptors
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