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文献和实验Anti-c-erb1B2 Ribozyme for Gene Therapy of Breast Cancer
The application of antioncogene ribozyme in the gene therapy of breast cancer by means of recombinant adenoviral vector is dicussed in this chapter. We have shown that recombinant adenovirus encoding anti-cerbB2 ribozyme inhibited the breast
Anti-MDR1 Ribozyme Gene Therapy
Multidrug resistance (MDR) in human cancer seriously limits the efficacy of anticancer agents. Circumvention of MDR is, thus, one of the urgent goals for successful cancer chemotherapy.
Clinical Development of Antisense Oligonucleotides as Anti-Cancer Therapeutics
Antisense oligonucleotides (AONs) are one of the several types of “antisense therapeutics” designed to modulate specific gene expression at the mRNA level. Although antisense strategies also include ribozymes (RNA enzyme) and, more recently
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