- ￥3000 - 3999
- Abbiotec
- 美国
- 250836
- 2025年07月14日
- E, WB, IHC
- Mouse
- H, M, R
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PSEN1.
- 亚型：
Mouse Ig
- 形态：
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆抗体
- 标记物：
见下方详细说明
- 适应物种：
H, M, R
- 宿主：
Mouse
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
Presenilin-1 (N-term)
- 抗体英文名：
Presenilin-1 (N-term) Antibody
- 抗体名：
Presenilin-1 (N-term) Antibody
- 规格：
0.1 mg
Presenilin-1 (N-term) Antibody产品详细介绍：
| 产品名称： | Presenilin-1 (N-term) Antibody |
| 说明书： | http://www.abbiotec.com/antibodies/presenilin-1-n-term-antibody【参考图片】 |
| 货号： | 250836 |
| 规格： | 0.1 mg |
| 产品描述： | Presenilin-1 (PSEN1) is the catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 and PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Presenilins are also involved in the cleavage of the Notch receptor, either by regulating gamma-secretase activity or by direct proteolytic activity. Three alternative splice variants of PSEN1 have been identified. Defects in PSEN1 are a cause of familial early-onset Alzheimer disease type 3, the most severe form of the disease. |
| 克隆类型： | Mouse Polyclonal Antibody |
| 亚型： | Mouse Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PSEN1. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
| 别名： | Presenilin-1; Protein S182; Presenilin-1 NTF subunit; Presenilin CTF subunit; PSEN1; AD3; PS1; PSNL1 |
| 形态： | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验The Phosphorylation of Presenilin Proteins
The phosphorylation of presenilin (PS) proteins was initially analyzed in cultured cells overexpressing the respective proteins. These studies revealed that the homologous PS proteins are differentially phosphorylated in vivo. Fulllength PS
In the field of therapeutic recombinant proteins, monoclonal antibodies (mAbs) have achieved a rising success with more than 30 mAbs that have reached the market in the past 20 years. From a structural standpoint, one of the most important
to protect the antibody. These should be stored in smaller aliquots (about 1 ml) and frozen for long term storage though the protected solution is also stable for months at four degrees. Ascites fluid: This is a bit more problematic as it may contain
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