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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
polypeptide, sealed storage, away from moisture
- 英文名:
BIP-V5; BAX Inhibiting Peptide V5
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
579492-81-2
- 规格:
5 mg/10 mg/25 mg/50 mg
| 规格: | 5 mg | 产品价格: | ¥950.0 |
|---|---|---|---|
| 规格: | 10 mg | 产品价格: | ¥1400.0 |
| 规格: | 25 mg | 产品价格: | ¥3000.0 |
| 规格: | 50 mg | 产品价格: | ¥5000.0 |
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Bax inhibitor peptide V5
CAS No. : 579492-81-2
MCE 国际站:Bax inhibitor peptide V5
产品活性:Bax inhibitor peptide V5 (BIP-V5) 是一种 Bax 诱导凋亡的抑制剂,主要用于癌症研究。
研究领域:Apoptosis
作用靶点:Bcl-2 Family | Apoptosis
In Vitro: Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively.
In Vivo: Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model.
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文献和实验Random Mutagenesis of Peptide Aptamers as an Optimization Strategy for Inhibitor Screening
Accumulating work over the past decade has shown that peptide aptamer screening represents a valid strategy for inhibitor identification that can be applied to a variety of different targets. Because of the screening method in cells
Differential Expression of Apoptosis-Associated Genes bax and bcl-2 in Ovarian Cancer
either as inhibitors (e.g., bcl-2, bcl-xl, mcl- 1) or promoters (e.g., bcl-xs, bax, bak, bad) of apoptosis (1 -3 ). The chromosomal translocation t(14;18), leading to overexpression of the Bcl-2 protein was first described in human B-cell lymphoma (4 ). Later
Predicting Peptide Retention Times for Proteomics
. Krokhin, O.V. and Spicer, V. 2009. Peptide retention standards and hydrophobicity indexes in reversed‐phase high‐performance liquid chromatography of peptides. Anal Chem. 81:9522‐9530
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