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- 详细信息
- 技术资料
- 保存条件：
4°C, protect from light
- 英文名：
(+)-Bicuculline
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
485-49-4
- 规格：
10 mM * 1 mL/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥700.0 |
| 规格： | 100 mg | 产品价格： | ￥1000.0 |
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Bicuculline
CAS No. : 485-49-4
MCE 国际站：Bicuculline
产品活性：Bicuculline ((+)-Bicuculline; d-Bicuculline) 作为惊厥生物碱，是一种竞争性的神经递质 GABAA 受体拮抗剂 (IC50=2 μM)。Bicuculline还能阻断 Ca2+ 激活钾 (SK) 通道，并随后阻断慢后超极化(slow AHP)。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：GABA Receptor
In Vitro: Bicuculline ((+)-Bicuculline; d-Bicuculline) (1 and 3 μM) attains the maximal response of GABA. Bicuculline appears to shift the dose–response curves of GABA in parallel to the right without decreasing GABA maximal response, suggesting that it is a competitive antagonist at α1β2γ2L GABAA receptors.
In Vivo: Bicuculline can be used in animal modeling to construct convulsion models.
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