4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)

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本试剂(4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑)
仅供科研实验使用,不得用于其他用途！

简介：
货 号：LC1-S-1700
名 称：4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑
别 名：SB 202190 Free Base
C A S ：152121-30-7
分子量：331.34
分子式：C20H14FN3O
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
文 献：SB202190, a pyridinyl imidazole, inhibits p38 kinase activity in vivo through competition with ATP. Young, P.R., et al. "Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site." J. Biol. Chem. 272: 12116-12121 (1997). Induces apoptosis through activation of cysteine protease (CPP32)-like caspases . Nemoto, S., et al. "Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase." J Biol Chem. 273: 16415-16420 (1998). Blocks both lipopolysaccharide (LPS)-induced gene expression and nitric oxide (NO)-induced stabilization of interleukin (IL)-8 mRNA in monocytes. Manthey, C.L., et al. "SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes." J. Leukoc. Biol. 64: 409-417 (1998). Ma, P., et al. "Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation." J. Leukoc. Biol. 76: 278-287 (2004).