维甲酰酚胺

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本试剂(维甲酰酚胺)
仅供科研实验使用,不得用于其他用途！

简介：
货 号：LC2-F-4077
名 称：维甲酰酚胺
别 名：Fenretinide
C A S ：65646-68-6
分子量：391.55
分子式：C26H33NO2
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 90 mg/mL; soluble in ethanol at 25 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-5 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
文 献：Fenretinide is a vitamin A analogue and has been used as a chemopreventive retinoid for women at risk of developing contralateral breast cancer. Fenretinide treatment resulted in a significant risk reduction of second breast cancer in premenopausal women after 15 year followups, which is remarkable at younger ages, and persisted several years after treatment cessation. Veronesi, U., et al. "Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer." Ann. Oncol. 17: 1065-1071 (2006). Fenretinide is concentrated by breast tissue in patients. Mehta, R.G., et al. "Distribution of fenretinide in the mammary gland of breast cancer patients." Eur. J. Cancer 27: 138-141 (1991). The mechanism of action for fenretinide is not yet fully understood. It may inhibit cell growth through induction of apoptosis, not differentiation, and through vitamin A receptor-dependent and -independent mechanisms. Cazzaniga, M., et al. "Fenretinide (4-HPR): a preventive chance for women at genetic and familial risk?" J. Biomed. Biotechnol. 2012: 172897 (2012).