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- 文献和实验
- 技术资料
- 保存条件：
见说明书
- 保质期：
＞1年
- 英文名：
PP242 Free Base
- 库存：
期货2-3周
- 供应商：
上海经科化学科技有限公司
- CAS号：
1092351-67-1
- 规格：
10mg
供应商：上海经科化学科技有限公司
服务热线：400-0199-638
QQ:472482400(上海经科）
微信号：shjkchem
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本试剂(PP242)
仅供科研实验使用,不得用于其他用途！
货 号：P-6666
名 称：PP242
别 名：PP242 Free Base
C A S ：1092351-67-1
分子量：308.34
分子式：C16H16N6O
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A
文 献：PP242 inhibits mTORC1 more effectively than rapamycin. Unlike rapamycin, PP242 inhibits both mTORC1 and mTORC2. PP242 blocks the phosphorylation of Akt at S473 and prevents its activation. PP242 inhibits the proliferation of primary cells more efficiently than rapamycin. Unlike rapamycin, it also inhibits cap-dependent translation under conditions. Feldman, M.E., et al. "Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2." PLoS Biol. 7: 371-383 (2009). PP242, but not rapamycin, induced death of mouse and human leukemia cells in vitro. In vivo, PP242 delayed leukemia onset and enhanced the effects of the front-line tyrosine kinase inhibitors more effectively than does rapamycin. However, PP242 had much weaker effects than rapamycin on the proliferation of normal lymphocytes. Janes, M.R., et al. "Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor." Nat. Med. 16: 205-213 (2010). PP242 inhibited basal serum- and glucocorticoid-inducible protein kinase 1 (SGK1) activity and prevented insulin- and dexamethasone-induced SGK1 activation, possibly by suppressing TORC1/2. It inhibited basal Na+ absorption modestly and insulin/dexamethasone-induced Na+ transport substantially. Mansley, M.K. and Wilson, S.M. "Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2." Br. J. Pharmacol. 161: 1778-1792 (2010). PP242 inhibited growth and induced apoptosis of multiple myeloma (MM) cells more effectively than rapamycin. PP242 was an effective inhibitor of primary MM cells in vitro and growth of 8226 cells in mice. Combining bortezomib with PP242 resulted in synergistic anti-MM effects. Hoang, B., et al. "Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor." Blood 116: 4560-4568 (2010). PP242 significantly augmented histone deacetylase inhibitor-induced apoptosis in hepatocellular carcinoma cells. Shao, H., et al. "Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo." J. Hepatol. Aug 8 (2011) [Epub ahead of print].
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文献和实验caga 我是临床的研究生，想做PP2A的课题，哪个强人给点意见，谢谢 chuckdouble caga wrote: 我是临床的研究生，想做PP2A的课题，哪个强人给点意见，谢谢 这个问题太抽象了，不明白你想做什么。 katerlisa 我也要做这个方向的课题，以后多交流 本文由丁香园论坛提供，想
糖类抗原242（CA-242）检测的临床意义： CA-242是一种新型的肿瘤标志物，是一种粘蛋白糖类抗原，1985年由Lindholm等人发现，它是人结-直肠癌细胞株Colo205经杂交瘤技术免疫小鼠获得的单克隆抗体CA-242所能识别的一种抗原，其抗原决定簇是一种新的唾液酸化的糖。免疫化学研究证明，CA-242不同于现有的肿瘤相关粘蛋白抗原，如CA-199，CA-50等。CA-242抗原决定簇的表达如同唾液酸化路易思A抗原（例如CA199）SialyLewis（SLea
lingwu 酪氨酸激酶抑制剂PP1和PP2有什么区别？如何选择， 急切想知道，谢谢！ ylhuang0502 首先纠正一下， PP1和PP2都不是酪氨酸激酶的通用抑制剂，两者均为Src family kinase的选择性抑制剂。其中PP2更常用些，两者的差异很小，化学结构非常相似，两者均不是Src family kinase 特异性抑制剂，两者均可抑制别的激酶的活性，，比如： The Src
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