Nintedanib

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本试剂(Nintedanib)
仅供科研实验使用,不得用于其他用途！

简介：
货 号：N-9077
名 称：Nintedanib
别 名：Nintedanib Free Base
C A S ：656247-17-5
分子量：539.62
分子式：C31H33N5O4
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 25 mg/mL with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
文 献：Nintedanib significantly decreased blood vessel area and inhibited tumour growth. Zips, D., et al. "Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas." Radiother. Oncol. 92: 405-410 (2009). A reproducible hepatic perfusion index (HPI) was determined by using quantified gadopentetate dimeglumine (Gd-DTPA) concentration. The HPI decreased significantly at 28 days after treatment with nintedanib. HPI may be useful for monitoring antiangiogenic treatment response of hepatic metastases. Miyazaki, K., et al. "Quantitative mapping of hepatic perfusion index using MR imaging: a potential reproducible tool for assessing tumour response to treatment with the antiangiogenic compound BIBF 1120, a potent triple angiokinase inhibitor." Eur. Radiol. 18: 1414-1421 (2008).