Forskolin

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本试剂(Forskolin)
仅供科研实验使用,不得用于其他用途！

简介：
货 号：F-9929
名 称：Forskolin
别 名：Forskolin
C A S ：66575-29-9
分子量：410.5
分子式：C22H34O7
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 160 mg/mL; soluble in ethanol at 50 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
文 献：Forskolin is a naturally occurring diterpene from the Indian plant, Coleus forskohlii, that works as an activator of adenylate cyclase resulting in an increase in the intracellular concentration of cAMP. Laurenza, A., et al. "Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?" Trends Pharm. Sci. 10: 442-447 (1989). Barber, R. and Goka, T.J. "Adenylate cyclase activity as a function of forskolin concentration." J. Cyclic Nucleotide Protein Phosphor. Res. 10: 23-29 (1985). Forskolin acts as a smooth muscle relaxant and vasodilator in a concentration-dependent manner that affects both cytoplasmic calcium levels and contractile element calcium sensitivity. Abe, A. and Karaki, H.J. "Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle." J. Pharmacol. Exp. Ther. 249: 895-900 (1989). Forskolin is an inhibitor of mammalian glucose transporters and of a bacterial galactose-H+ transporter, GalP. Joost, H.G. and Steinfelder, H.J. "Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter." Mol. Pharmacol. 31: 279 (1987). Martin, G.E., et al. "Forskolin specifically inhibits the bacterial galactose-H+ transport protein, GalP." J. Biol. Chem. 269: 24870-24877 (1994). Forskolin blocks PKC-activated ERK1 and ERK2 tyrosine phosphorylation and inhibits PKC-stimulated MAPK and Raf-1 activities in mouse bone-forming cells (MC3T3-E1 osteoblasts). Siddhanti, S.R., et al. "Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts." Endocrinology. 136: 4834-4841 (1995).