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- A-1040
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
见说明书
- 保质期：
＞1年
- 英文名：
Ascomycin
- 库存：
期货2-3周
- 供应商：
上海经科化学科技有限公司
- CAS号：
104987-12-4
- 规格：
25mg
供应商：上海经科化学科技有限公司
服务热线：400-0199-638
QQ:472482400(上海经科）
微信号：shjkchem
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本试剂(Ascomycin)
仅供科研实验使用,不得用于其他用途！
货 号：A-1040
名 称：Ascomycin
别 名：Ascomycin
C A S ：104987-12-4
分子量：792.01
分子式：C43H69NO12
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 65 mg/mL; soluble in ethanol at 50 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubilit. Disposal: A.
文 献：Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9: 69-77 (2000). Mollison, K.W., et al. "A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases." J. Invest. Dermatol. 112: 729-738 (1999). Antimalarial effects of ascomycin appear to be independent of its immunosuppressive properties. Monaghan, P., et al. "Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds." J. Infect. Dis. 191: 1342-1349 (2005). FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14: 277-286 (1994).
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文献和实验of calibrators and internal standards versus concentrations. MRMs used are ascomycin (m /z 809.5 → 756.5), cyclosporine A (m /z 1,219.9 → 1,203.1), cyclosporine D (m/z 1,234.0 → 1,217.0), sirolimus (m /z 931.6 → 864.5), and tacrolimus (m/z 821.5 → 768.4).
:3); flow rate 0.8 mL/min; and a run-time of 2.8 min. The first and third quadrupoles were set to detect the ammonium adduct ion and a high mass fragment of tacrolimus (m/z 821.5→768.3), and of an internal standard (ascomycin) (m/z 901.8→834.4). The lower
Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS)
column. The first and third quadrupoles were set to detect the ammonium adduct ion and a high mass fragment of sirolimus (m/z 931.8→864.6), and of an internal standard (ascomycin) (m/z 809.5→756.5). The lower limit of quantification of this method is 2.5
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