- ￥1568
- LC labs
- 美国
- A-1803
- 2025年07月11日
16 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
见说明书
- 保质期：
＞1年
- 英文名：
A-769662
- 库存：
期货2-3周
- 供应商：
上海经科化学科技有限公司
- CAS号：
844499-71-4
- 规格：
10mg
供应商：上海经科化学科技有限公司
服务热线：400-0199-638
QQ:472482400(上海经科）
微信号：shjkchem
活动：消费积分可换充值卡！
本试剂(A-769662)
仅供科研实验使用,不得用于其他用途！
货 号：A-1803
名 称：A-769662
别 名：A-769662
C A S ：844499-71-4
分子量：360.39
分子式：C20H12N2O3S
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 33 mg/mL; soluble in ethanol at 5 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous sol. Disposal: A.
文 献：A-769662 is a potent and reversible activator of AMP-activated protein kinase (AMPK). AMPK is an αβγ heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the β1 subunit. A-769662 activates AMPK through the β subunit carbohydrate-binding module and the γ subunit but not the AMP-binding sites. Scott, J.W., et al. "Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes." Chem. Biological 15: 1220-1230 (2008). A-769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 µM. A-769662 decreased liver malonyl CoA levels of Sprague Dawley rats and the respiratory exchange ratio, VCO2/VO2, and thus increased rate of whole-body fatty acid oxidation. A-769662 reduced hepatic expression of PEPCK, G6Pase, and FAS, decreased body weight gain, lowered plasma glucose by 40%, and reduced both plasma and liver triglyceride levels in ob/ob mice. Cool, B., et al. "Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome." Cell Metab. 3: 403-416 (2006). A-769662 induces allosteric activation of AMP-activated protein kinase (AMPK) and inhibition of dephosphorylation of AMPK on Thr-172, similar to the effects of AMP. Sanders, M.J., et al. "Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family." J. Biol. Chem. 282: 32539-32548 (2007). The effects of A-769662 are not dependent on the upstream kinase used in intact cells. Göransson, O., et al. "Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase." J. Biol. Chem. 282: 32549-32560 (2007). In skeletal muscle, A-769662 activates β1-containing AMPK complexes, but induces glucose uptake via a PI3 kinase-dependent pathway. Treebak, J.T., et al. "A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3 kinase-dependent pathway in mouse skeletal muscle." Am. J. Physiol. Cell Physiol. 297: C1041-C1052 (2009). A-769662 inhibits 3T3-L1 adipocyte differentiation and may be used to treat obesity. Zhou, Y., et al. "Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis." Biol. Pharm. Bull. 32: 993-998 (2009). A-769662 inhibited the function of the 26S proteasome via an AMPK-independent mechanism. Moreno, D., et al. "A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism." FEBS Lett. 582: 2650-2654 (2008). Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use. This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验相关实验
磷酸化和 S6 激酶的高水平，但这种信号在低氧下培养的细胞中却不存在。 图片来源：Molecular Cell 上述的实验证明，低氧环境下的衰老细胞表现为 mTOR 通路的下调，而 mTOR 通路的抑制可由多种机制实现，包括 AMPK，一种在低氧环境中帮助维持能量平衡的传感器。此前有报道指出，二甲双胍是一种具有激活 AMPK 等多种分子功能的抗糖尿病药物，可降低常氧衰老细胞的 SASP。 因此，研究人员通过基因过表达或选择性 AMPK 激活剂 A769662 对细胞进行处理，结果发现，在常氧衰老
技术资料暂无技术资料 索取技术资料
A-769662
￥1568
