alpha-Asaroneα-细辛脑,2883-98-9

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alpha-Asarone

CAS No. : 2883-98-9

MCE 国际站：alpha-Asarone

产品活性：alpha-Asarone (α-Asarone) 是菖蒲属中主要的活性物质，具有抗抑郁等功效。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GABA Receptor

In Vitro: The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.

In Vivo: The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.

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