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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
(-)-(S)-Equol
- 库存:
10
- 供应商:
TargetMol
- CAS号:
531-95-3
- 规格:
1 mg/50 mg/500 mg/25 mg/10 mg/5 mg/100 mg/1 mL
| 规格: | 1 mg | 产品价格: | ¥185.0 |
|---|---|---|---|
| 规格: | 50 mg | 产品价格: | ¥1730.0 |
| 规格: | 500 mg | 产品价格: | ¥5930.0 |
| 规格: | 25 mg | 产品价格: | ¥970.0 |
| 规格: | 10 mg | 产品价格: | ¥578.0 |
| 规格: | 5 mg | 产品价格: | ¥413.0 |
| 规格: | 100 mg | 产品价格: | ¥2580.0 |
| 规格: | 1 mL | 产品价格: | ¥455.0 |
Product Introduction
Bioactivity
英文名:(-)-(S)-Equol
描述:(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.

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文献和实验Enzymatic Synthesis of (S)-Phenylalanine and Related (S)-Amino Acids by Phenylalanine Dehydrogenase
substituents in the reductive amination reaction. Optically pure (S)-phe and other (S)-amino acids are quantitatively synthesized from their oxo-analogs using PheDH, with a regeneration of NADH by formate dehydrogenase from Candida boidinii No. 2201. Acetone
have led to the conclusion that CYP2C19 is a major P450 responsible for (S)-mephenytoin 4’-hydroxylation activity in human liver microsomes (1 , 2 ). This is supported by the finding that cDNA-expressed CYP2C19 has a 50-to lOO-fold greater turnover number
A reverse-phase, high-performance liquid chromatography method is described for the quantification of 4′-hydroxymephenytoin formed enzymatically from 14 C-labeled (S )-mephenytoin following incubation with cDNA-expressed CYP2C19 or human
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