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- MedChemExpress(MCE)
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- HY-13591
- 2026年08月01日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
IB-MECA; CF-101
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
152918-18-8
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1347.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 25 mg | 产品价格： | ￥4000.0 |
| 规格： | 50 mg | 产品价格： | ￥6400.0 |
| 规格： | 100 mg | 产品价格： | ￥9900.0 |
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Piclidenoson
CAS No. : 152918-18-8
MCE 国际站：Piclidenoson
产品活性：Piclidenoson (IB-MECA) 是一种首创的，具有口服活性的，选择性的腺苷 A3 受体 (A3AR) 激动剂。Piclidenoson 在不同类型的癌细胞如黑色素瘤、白血病中表现出抗增殖和诱导凋亡 (apoptosis) 的作用。Piclidenoson 可用于自身免疫性炎症疾病和 COVID-19 的研究。
研究领域：GPCR/G Protein | Apoptosis
作用靶点：Adenosine Receptor | Apoptosis
In Vitro: Piclidenoson is able to inhibit Forskolin (HY-15371)-stimulated cAMP levels with EC50s of 0.82 μM and 1.2 μM in OVCAR-3 cells and Caov-4 cells, respectively.
?Piclidenoson (0.0001-100 μM; 48 hours) significantly reduces cell viability in a dose-dependent manner in human ovarian cancer cell lines, with IC50s of 32.14 μM and 45.37 μM for OVCAR-3 and Caov-4 cells, respectively.
?Piclidenoson (0.001-100 μM; 48 hours) induces apoptosis in ovarian cancer cell line through the caspase pathway.
?Piclidenoson induces apoptosis via the mitochondrial signaling pathway.
In Vivo: Piclidenoson (105 μg/kg; i.p.) enhances survival of γ-irradiated mice.
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