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4°C, sealed storage, away from moisture
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货期：1-2天
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- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1045.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥380.0 |
| 规格： | 5 mg | 产品价格： | ￥950.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
| 规格： | 50 mg | 产品价格： | ￥6400.0 |
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L-778123 hydrochloride
CAS No. : 253863-00-2
MCE 国际站：L-778123 hydrochloride
产品活性：L-778123 hydrochloride 是 FPTase 和 GGPTase-I 双重抑制剂, IC50 值分别为2 nM 和 98 nM。
研究领域：Metabolic Enzyme/Protease
作用靶点：Farnesyl Transferase
In Vitro: L-778123 hydrochloride alone does not have obvious cytotoxicity on HT-29 and A549 cell lines (IC50: >100 μM), but can generate synergistic effects with Doxorubicin (HY-15142A), with the decreased IC50s of 1.72 and 1.52 μM respectively.
L-778123 hydrochloride inhibits myeloid leukemia cell proliferation with IC50 values of 0.2 μM-1.8 μM for cell lines, and 0.1 μM-161.8 μM in primary samples.
L-778123 (0-1 μM, 12 h; or 5 μM, 6 h) hydrochloride inhibits H-RAS prenylation in HL-60 cells, and inhibits phosphorylated MEK-1/2 level (5 μM, 24 h).
L-778123 (0-100 μM, 72 h) hydrochloride inhibits lymphocyte activation (marker: CD71 or CD25) and function in human PBMCs.
In Vivo: L-778123 (50 mg/kg/day, infusion, 7 days) hydrochloride inhibits both HDJ2 and Rap1A prenylation in PBMCs of dogs, but without inhibition in Ki-Ras prenylation.
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文献和实验左旋茶氨酸 L-theanine 即谷酰基乙胺。是从茶叶中发现的（ Y． Saka-to， 1950）。与谷氨酸同样机制合成。
Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
L-DOPA (L-3,4-Dihydroxyphenylalanine)
The nonprotein amino acid, 3,4-dihydroxyphenylalanine (L -DOPA) (Fig. 1) is present in high concentrations (about 3–6%) in Mucuna spp. The in vitro addition of L -DOPA to the red blood cells from individuals deficient in glucose 6-phosphate
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