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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
803647-40-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥880.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1350.0 |
| 规格： | 25 mg | 产品价格： | ￥2800.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
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NSC59984
CAS No. : 803647-40-7
MCE 国际站：NSC59984
产品活性：NSC59984 通过 MDM2 和泛素-蛋白酶体途径而诱导突变型 p53 蛋白降解。NSC59984 靶向 GOF 突变体 p53，并刺激 p73 恢复 p53 途径的信号传导。
研究领域：Apoptosis
作用靶点：MDM-2/p53
In Vitro: NSC59984 specifically restores p53 pathway signaling in mutant p53-expressing human colorectal cancer cells. NSC59984 induces cell death in tumor cells but not normal cells with little or no genotoxicity. NSC59984 induces mutant p53 protein degradation through MDM2-mediated ubiquitination in cancer cells. NSC59984 restores p53 pathway signaling through activation of p73. NSC59984 induces p73-dependent cell apoptosis in cancer. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells.
In Vivo: NSC59984 synergizes with CPT11 to induce cell death in mutant p53-expressing colorectal cancer cells and inhibits mutant p53-associated colon tumor xenograft growth in a p73-dependent manner.
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文献和实验Evaluation of Proliferation of Neural Stem Cells In Vitro and In Vivo
two basic protocols for the detection of the proliferation of neural stem cells (NSC). The first one addresses cell proliferation in cultures, starting with primary cell cultures isolated from the mouse subventricular zone (SVZ), in which SVZ?derived NSC
cerevisiae 39. ASAP http://www.bioinformatics.ucla.edu/ASAP Alternative spliced isoforms 40. CUTG http://www.kazusa.or.jp/codon/ Codon usage tables 41. DBTBS http://elmo.ims.u-tokyo.ac.jp/dbtbs/ Bacillus subtilis binding factors and promoters 42
仪表与分析检测》、《分析测试技术与仪器》、《国外分析仪器技术与应用》、《分析测试仪器通讯》、《理化检验(化学分册)》等23种中文期刊及Anal．Chem・，J．Chromatogr．A，Chromatographia，J．HighResol．Chromatogr・，J．Liq．Chrom．＆Rel．Techn01．等与色谱科学相关的国外学术期刊。此外，我们对在此期间召开的第12次全国色谱学术报告会(The l2th National Symposium of Chromatography，NSCⅫ
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