STING agonist-1

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STING agonist-1

CAS No. : 702662-50-8

MCE 国际站：STING agonist-1

产品活性：STING agonist-1 (G10) 是一种人类特异性 STING 激动剂, 针对新出现的甲病毒, 可引发抗病毒活性。G10 能有效抑制甲病毒属 VEEV 复制, IC₉₀ 值为 24.57 μM。

研究领域：Immunology/Inflammation  |  Anti-infection

作用靶点：STING  |  Virus Protease

In Vitro: G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts.
G10 is an indirect activator of human STING-dependent phenotypes.
G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling.
STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity.
G10 induces STING-dependent synthesis and secretion of bioactive interferon.
G10 induces innate antiviral mRNA expression in primary human cells.

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